Other ways to search: Events Calendar | UTHSC | UTHSC News

List of Selected Publications

Abdul Majid, Fasilat Oluwakemi Hassan, Monirul Md Hoque, Olaoluwa Joy Gbadegoye, and Djamel Lebeche: Bioactive compounds and cardiac fibrosis: Current insight and future prospect. J. Cardiovasc. Dev. Dis. 2023, 10(7), 313; https://doi.org/10.3390/jcdd10070313

Akhilesh Kumar Bajpai, Qingqing Gu, Buyan-Ochir Orgil, Fuyi Xu, Carolina Torres Rojas, Wenyuan Zhao, Chen Chen, Athena Starlard-Davenport, Djamel Lebeche, Jeffrey A. Towbin, Enkhsaikhan Purevjav, Lu Lu1, Wenjing Zhang. Cardiac copper content and its relationship with heart physiology: Insights based on quantitative genetic and functional analyses using BXD family mice. 2023, Front. Cardiovasc. Med. 10:1089963.

Qingqing Gu, Buyan-Ochir Orgil, Akhilesh Kumar Bajpai, Yufeng Chen, David Ashbrook, Athena Starlard-Davenport, Djamel Lebeche, Jeffrey A. Towbin, Enkhsaikhan Purevjav, Hongzhuan Sheng, Lu Lu. Unravelling the role of Tnni3k in cardiac function and cardiovascular diseases using systems genetics approaches. Int. J. Mol. Sci. 2023, 24(16), 12759; https://doi.org/10.3390/ijms241612759 

Cai, X., Allison, M. A., Ambale-Venkatesh, B., Jorgensen, N. W., Lima JAC, Muse, E. D., McClelland, R. L., Shea, S., & Lebeche, D. (2022). Resistin and risks of incident heart failure subtypes and cardiac fibrosis: the Multi-Ethnic Study of Atherosclerosis. ESC Heart Failure, 9(5), 3452–3460. https://doi.org/10.1002/ehf2.14064

Mangangcha, I. R., Brojen Singh, R. K., Lebeche, D., & Ali, S. (2022). Xanthone glucoside 2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one binds to the ATP-binding pocket of glycogen synthase kinase 3β and inhibits its activity: implications in prostate cancer and associated cardiovascular disease risk. Journal of Biomolecular Structure & Dynamics, 40(17), 7868–7884. https://doi.org/10.1080/07391102.2021.1902857

Zhao, B., Bouchareb, R., & Lebeche, D. (2022). Resistin deletion protects against heart failure injury by targeting DNA damage response. Cardiovascular Research, 118(8), 1947–1963. https://doi.org/10.1093/cvr/cvab234

Kaur, K., Hadas, Y., Kurian, A. A., Żak, M. M., Yoo, J., Mahmood, A. Q., Girard, H., Komargodski, R., Io, T., Santini, M. P., Sultana, N., Sharkar MTK, Magadum, A., Fargnoli, A., Yoon, S., Chepurko, E., Chepurko, V., Eliyahu, E., Pinto, D., … Zangi, L. (2021). Direct reprogramming induces vascular regeneration post muscle ischemic injury. Molecular Therapy : The Journal of the American Society of Gene Therapy, 29(10), 3042–3058. https://doi.org/10.1016/j.ymthe.2021.07.014

Hamdani, N., Costantino, S., Mügge, A., Lebeche, D., Tschöpe, C., Thum, T., & Paneni, F. (2021). Leveraging clinical epigenetics in heart failure with preserved ejection fraction: a call for individualized therapies. European Heart Journal, 42(20), 1940–1958. https://doi.org/10.1093/eurheartj/ehab197

Bouchareb, R., & Lebeche, D. (2021). Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro. Journal of Visualized Experiments : JoVE, 171. https://doi.org/10.3791/62419

Singh, R., Kaundal, R. K., Zhao, B., Bouchareb, R., & Lebeche, D. (2021). Resistin induces cardiac fibroblast-myofibroblast differentiation through JAK/STAT3 and JNK/c-Jun signaling. Pharmacological Research, 167, 105414. https://doi.org/10.1016/j.phrs.2020.105414

Magadum, A., Singh, N., Kurian, A. A., Sharkar MTK, Sultana, N., Chepurko, E., Kaur, K., Żak, M. M., Hadas, Y., Lebeche, D., Sahoo, S., Hajjar, R., & Zangi, L. (2021). Therapeutic Delivery of Pip4k2c-Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart. Advanced Science (Weinheim, Baden-Wurttemberg, Germany), 8(10), 2004661. https://doi.org/10.1002/advs.202004661

Bouchareb, R., Guauque-Olarte, S., Snider, J., Zaminski, D., Anyanwu, A., Stelzer, P., & Lebeche, D. (2021). Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis. JACC. Basic to Translational Science, 6(1), 25–39. https://doi.org/10.1016/j.jacbts.2020.11.008

Bouchareb, R., Katz, M., Saadallah, N., Sassi, Y., Ali, S., & Lebeche, D. (2020). Boron improves cardiac contractility and fibrotic remodeling following myocardial infarction injury. Scientific Reports, 10(1), 17138. https://doi.org/10.1038/s41598-020-73864-w

Lebeche, D. (2019). Response to ‘Metabolism reprogramming: new insights of Dlk1 into cardiac fibrosis’. European Heart Journal, 40(43), 3575. https://doi.org/10.1093/eurheartj/ehz604

Rodriguez, P., Sassi, Y., Troncone, L., Benard, L., Ishikawa, K., Gordon, R. E., Lamas, S., Laborda, J., Hajjar, R. J., & Lebeche, D. (2019). Deletion of delta-like 1 homologue accelerates fibroblast-myofibroblast differentiation and induces myocardial fibrosis. European Heart Journal, 40(12), 967–978. https://doi.org/10.1093/eurheartj/ehy188

Mathiyalagan, P., Adamiak, M., Mayourian, J., Sassi, Y., Liang, Y., Agarwal, N., Jha, D., Zhang, S., Kohlbrenner, E., Chepurko, E., Chen, J. P., Trivieri, M. G., Singh, R., Bouchareb, R., Fish, K., Ishikawa, K., Lebeche, D., Hajjar, R. J., & Sahoo, S. (2019). FTO-Dependent N(6)-Methyladenosine Regulates Cardiac Function During Remodeling and Repair. Circulation, 139(4), 518–532. https://doi.org/10.1161/CIRCULATIONAHA.118.033794

Kawai, H., Chaudhry, F., Shekhar, A., Petrov, A., Nakahara, T., Tanimoto, T., Kim, D., Chen, J. P., Lebeche, D., Blankenberg, F. G., Pak, K. Y., Kolodgie, F. D., Virmani, R., Sengupta, P., Narula, N., Hajjar, R. J., Strauss, H. W., & Narula, J. (2018). Molecular Imaging of Apoptosis in Ischemia Reperfusion Injury With Radiolabeled Duramycin Targeting Phosphatidylethanolamine: Effective Target Uptake and Reduced Nontarget Organ Radiation Burden. JACC. Cardiovascular Imaging, 11(12), 1823–1833. https://doi.org/10.1016/j.jcmg.2017.11.037

Singh, R., Moreno, P., Hajjar, R. J., & Lebeche, D. (2018). A role for calcium in resistin transcriptional activation in diabetic hearts. Scientific Reports, 8(1), 15633. https://doi.org/10.1038/s41598-018-34112-4

Bidwell, P. A., Liu, G. S., Nagarajan, N., Lam, C., Haghighi, K., Gardner, G., Cai, W. F., Zhao, W., Mugge, L., Vafiadaki, E., Sanoudou, D., Rubinstein, J., Lebeche, D., Hajjar, R., Sadoshima, J., & Kranias, E. G. (2018). HAX-1 regulates SERCA2a oxidation and degradation. Journal of Molecular and Cellular Cardiology, 114, 220–233. https://doi.org/10.1016/j.yjmcc.2017.11.014

Chemaly, E. R., Troncone, L., & Lebeche, D. (2018). SERCA control of cell death and survival. Cell Calcium, 69, 46–61. https://doi.org/10.1016/j.ceca.2017.07.001

Hammoudi, N., Jeong, D., Singh, R., Farhat, A., Komajda, M., Mayoux, E., Hajjar, R., & Lebeche, D. (2017). Empagliflozin Improves Left Ventricular Diastolic Dysfunction in a Genetic Model of Type 2 Diabetes. Cardiovascular Drugs and Therapy, 31(3), 233–246. https://doi.org/10.1007/s10557-017-6734-1

Tong, X., Kono, T., Anderson-Baucum, E. K., Yamamoto, W., Gilon, P., Lebeche, D., Day, R. N., Shull, G. E., & Evans-Molina, C. (2016). SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity. Diabetes, 65(10), 3039–3052. https://doi.org/10.2337/db16-0084

Kang, S., Dahl, R., Hsieh, W., Shin, A., Zsebo, K. M., Buettner, C., Hajjar, R. J., & Lebeche, D. (2016). Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders. The Journal of Biological Chemistry, 291(10), 5185–5198. https://doi.org/10.1074/jbc.M115.705012

Complete list of publications can be found in my NCBI Bibliography at:


and Google scholar at: